Math 2.0

Statistics Definition

Nelson–Aalen estimator

Builds on Hazard functionCensoringEstimator

Definition

Let (t~1,δ1),…,(t~n,δn)(\tilde t_1, \delta_1), \dots, (\tilde t_n, \delta_n) be right-censored observations of a lifetime, with δi=1\delta_i = 1 for an event and δi=0\delta_i = 0 for a censored time. Let t(1)<⋯<t(m)t_{(1)} < \dots < t_{(m)} be the distinct event times, djd_j the number of events at t(j)t_{(j)}, and nj=#{i:t~i≥t(j)}n_j = \#\set{i : \tilde t_i \ge t_{(j)}} the number at risk just before t(j)t_{(j)}. The Nelson–Aalen estimator of the cumulative hazard function HH is H^(t)=∑j : t(j)≤tdjnj,t≥0,\hat H(t) = \sum_{j \,:\, t_{(j)} \le t} \frac{d_j}{n_j}, \qquad t \ge 0, with the empty sum equal to 00.

Remarks

In counting process notation, with N(t)N(t) the number of observed events up to tt and Y(t)Y(t) the number at risk at tt, the estimator is H^(t)=∫0tdN(s)Y(s)\hat H(t) = \int_0^t \frac{dN(s)}{Y(s)}, with 0/0=00/0 = 0. A common variance estimator is ∑j:t(j)≤tdj/nj2\sum_{j : t_{(j)} \le t} d_j / n_j^2. The survival estimate e−H^(t)e^{-\hat H(t)} is at least the Kaplan–Meier estimate, since e−x≥1−xe^{-x} \ge 1 - x for all xx.

Example: for the observations 2,3+,5,72, 3^+, 5, 7, with 3+3^+ censored, (nj,dj)(n_j, d_j) is (4,1)(4, 1) at 22, (2,1)(2, 1) at 55 and (1,1)(1, 1) at 77. So H^=0\hat H = 0 on [0,2)[0, 2), 1/41/4 on [2,5)[2, 5), 3/43/4 on [5,7)[5, 7) and 7/47/4 from 77 on.

Non-example: the cumulative sum ∑t(j)≤tdj/n\sum_{t_{(j)} \le t} d_j / n, which divides by the initial sample size nn, is not the Nelson–Aalen estimator. It ignores that subjects leave the risk set, and it underestimates the cumulative hazard.

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  1. Censoring concept
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Further reading

  1. Web https://en.wikipedia.org/wiki/Nelson–Aalen_estimator
About this page
TagDBBE47SCG8
URIm2://DBBE47SCG8
Kinddefinition
WritingW0 stub
MSC62N02, 62G05
DefinesNelson–Aalen estimator
UsesHazard function, Censoring, Estimator

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